What is Biogaran Ivermectine 3mg?

Biogaran Ivermectine 3mg is a medication containing the active ingredient ivermectin, which is used to treat various parasitic infections. When using Biogaran Ivermectine 3mg, it’s important to know some key details and take the following precautions:

Uses: It is primarily used to treat infections caused by certain parasites, such as strongyloidiasis (intestinal threadworm) and onchocerciasis (river blindness). Dosage: The typical dosage is 3mg per tablet, and the exact dosage and duration depend on the specific infection and patient condition. It’s important to follow the prescribing doctor’s instructions. Monitor side effects: Be aware of common side effects like headache, dizziness, muscle pain, nausea, and diarrhea. These side effects are generally mild and temporary. However, if you experience more serious side effects such as severe skin rash, difficulty breathing, or swelling of the face, lips, or tongue, you should seek medical attention immediately. More serious side effects can occur but are rare. Report severe or unusual symptoms to your doctor immediately. Medical history: Inform your doctor about your medical history, especially if you have liver disease, asthma, or a weakened immune system. Allergies: Let your healthcare provider know if you have any allergies, particularly to ivermectin or any other medications. Pregnancy and breastfeeding: Discuss with your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as the medication may have effects on the baby. Drug interactions: Provide a list of all medications, supplements, and herbal products you are taking to avoid potential interactions. Hydration: Stay well-hydrated while taking the medication to help reduce the risk of side effects. Follow instructions: Take the medication exactly as prescribed, usually on an empty stomach with a full glass of water. Avoid alcohol: Limit alcohol consumption as it can increase the risk of liver problems and other side effects.

Administration: It is usually taken on an empty stomach with a full glass of water. The time it takes for ivermectin to work can vary depending on the type of infection being treated. Generally, you can expect to see improvement within 1 to 3 days after taking the medication. For some conditions, like rosacea, topical ivermectin may show results in about two weeks.

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Mechanism of action: Ivermectin works by paralyzing and killing the parasites, which are then expelled from the body. Imagine the parasite is like a small, unwanted guest in your house. Here’s how ivermectin works to get rid of it:

1. Finding the door: Ivermectin finds and attaches to special “doors” (chloride channels) on the surface of the parasite’s nerve and muscle cells.

2. Opening the door: Once attached, ivermectin opens these doors wide, allowing a flood of chloride ions (like a rush of water) to enter the parasite’s cells.

3. Overwhelming the system: This flood of chloride ions makes the inside of the parasite’s cells very negatively charged (like overloading an electrical circuit).

4. Paralysis and eviction: This overload paralyzes the parasite, making it unable to move or function, eventually leading to its death.

By targeting these specific “doors” and overwhelming the parasite’s system, ivermectin effectively evicts these unwanted guests from your body. This makes it a powerful tool against various parasites. See a more technical description below. A more technical description of mechanism of action: Ivermectin works by targeting the nervous system of parasites.

1. Binding to chloride channels: Ivermectin binds selectively and with high affinity to glutamate-gated chloride ion channels found in the nerve and muscle cells of invertebrates.

2. Increased permeability: This binding increases the permeability of the cell membrane to chloride ions, leading to an influx of chloride ions into the cells.

3. Hyperpolarization: The influx of chloride ions causes hyperpolarization of the cell membrane, which means the inside of the cell becomes more negatively charged.

4. Paralysis and death: This hyperpolarization results in paralysis and eventually death of the parasite, as it disrupts normal nerve signal transmission.

This mechanism is highly effective against a variety of parasites, making ivermectin a versatile antiparasitic medication.

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Ivermectin is primarily metabolized in the liver. Here’s a detailed look at the process:

• Liver metabolism: Ivermectin is metabolized by liver enzymes, predominantly by Cytochrome P450 3A4 (CYP3A4). Other enzymes like CYP3A5 and CYP2C9 also play a minor role.

• Metabolic reactions: The main metabolic reactions include C-hydroxylation and O-demethylation.

• Excretion: After metabolism, ivermectin and its metabolites are excreted almost exclusively in the feces over approximately 12 days. Less than 1% of the administered dose is excreted in the urine.
  

This efficient metabolism and excretion process help ensure that ivermectin is effectively cleared from the body.

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